Multiple gastric involvement by myeloid antigen CD13-positive non-secretory plasma cell leukaemia

Non-secretory multiple myeloma presenting as primary plasma cell leukaemia.

A case of non-secretory multiple myeloma presenting as primary plasma cell leukaemia in a 65 year old woman is presented. Bone pain was the initial clinical manifestation. Laboratory analysis showed 20% of circulating immature plasma cells. Despite the presence of osteolytic lesions, no M-component could be demonstrated in serum protein electrophoresis, and serum and urine immunoelectrophoresis...

Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells

Secreted matrix metalloproteinases (MMP)-2 and MMP-9 and membrane-anchored aminopeptidase-N/CD13 are abnormally expressed in human acute myeloid leukaemia (AML). We previously showed that CD13 ligation by anti-CD13 monoclonal antibodies can induce apoptosis in AML cells. Here, we assessed ADAM17 expression in primary blood blasts CD13+CD33+ from patients with AML. Primary AML cells expressed AD...

CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.

Dendritic cell (DC) Ag cross-presentation is generally associated with immune responses to tumors and viral Ags, and enhancement of this process is a focus of tumor vaccine design. In this study, we found that the myeloid cell surface peptidase CD13 is highly and specifically expressed on the subset of DCs responsible for cross-presentation, the CD8(+) murine splenic DCs. In vivo studies indica...

Uptake Inhibiting Receptor-Mediated Antigen Cross-Presentation and T Cell Responses by CD13 Regulates Dendritic Cell

Myeloid leukaemia.

This study was supported by the All India Institute of Medical Sciences, the Directorate General Armed Forces Medical Services, and the Indian Council of Medical Research, New Delhi. We are grateful to Lt.-Gen. S. N. Chatterjee, Director-General Armed Forces Medical Services, and Lt.-Gen. Ved Prakash, Director Medical Services (Army), and their staff for ungrudging support during all phases of ...